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试将两种不同pH的水杨酸毒扁豆碱滴眼剂用家兔缩瞳的药理指标进行了生物利用度比较。实验内容:(1)用不同剂量(0.0156、0.0313、0.0625和0.125mg/50μl/只),每个剂量用2只兔4只眼,连续测量瞳孔3～6小时,将药理效应强度的Imax(均值为0.37、0.51、0.53、0.57)绘制剂量-效应曲线。(2)将硼酸盐缓冲剂配制的0.05%水杨酸毒扁豆碱液(pH7.5,以下简称“水甲”)和用氯化钠调整渗透压的该制剂(pH 6,以下简称“水乙”)分别滴入4只家兔的左眼和右眼,剂量各50μl(1滴),观察其缩瞳效应后转换成相应的生物相药物浓度D_((t)),作药效-时间曲线。(3)将水甲和水乙滴眼后的药效-时间曲线下纸片重量称量后,按下列公式计算相对生物相的生物利
Two different pH of salicylic acid physostigmine eye drops pharmacological indicators of rabbit miosis were compared bioavailability. The contents of experiment: (1) The pupils were measured continuously for 3 ~ 6 hours with 2 rabbits (4 eyes) at different doses (0.0156, 0.0313, 0.0625 and 0.125 mg / Mean 0.37, 0.51, 0.53, 0.57) to plot the dose-response curve. (2) The formulation of 0.05% sodium salicylate physostigmine (pH7.5, hereinafter abbreviated as “A”) and a composition of osmotic pressure adjusted with sodium chloride (pH 6 or less) Abbreviated “water B”) were dripped into the left eye and the right eye of 4 rabbits respectively, each dose was 50μl (1 drop), and after the miosis effect was observed, it was converted to the corresponding drug concentration in the biological phase, D_ (t) , For efficacy - time curve. (3) the water A and water drops after eye drops of efficacy - time curve weighing the weight of the paper, according to the following formula to calculate the relative biological phase of biological Lee