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Astrocyte elevated gene-1(AEG-1) is associated with tumor genesis and progression in a variety of human cancers.This study aimed to explore the significance of AEG-l in glioma and investigate whether it correlated with radioresistance of glioma cells.Immunohistochemical staining showed that the intensity of AEG-l,CD133 and PPP6 c protein expression in glioma tissues increased significantly,mainly in the cytoplasm.The expression rate of AEG-l,CD133 and PPP6c were 85.9%(67/78),60.3%(47/78) and 65.8%(51/78),respectively.AEG-l expression was correlated with age(r=0.227,P=0.045),clinical stage(r=0.491,P<0.001) and clinical grade(r=0.450,P<0.001).No correlation was found between AEG-l expression and other clinicopathologic parameters(P>0.05).The expression of AEG-1 was positively correlated with the expression of CD133(r=0.240,P = 0.035) and PPP6c(r= 0.250,P = 0.027).In addition,retrieved data on TCGA implied co-occurrence of genomic alterations of AEG-l and PPP6 c in glioblastoma.Our findings indicate that AEG-l is positively correlated with CD133 and AEG-l expression.It may play an important role in the progression of glioma and may serve as potential novel marker of chemoresistance and radioresistance.
Astrocyte elevated gene-1 (AEG-1) is associated with tumor genesis and progression in a variety of human cancers. This study aims to explore the significance of AEG-1 in glioma and investigate whether it correlated with radioresistance of glioma cells. Immunohistochemical staining showed that the intensity of AEG-1, CD133 and PPP6c protein expression in glioma tissues increased significantly, mainly in the cytoplasm.The expression rate of AEG-1, CD133 and PPP6c were 85.9% (67/78), 60.3% (47 / R = 0.491, P <0.001) and clinical grade (r = 0.450, P <0.001) , P <0.001) .No correlation was found between AEG-1 expression and other clinicopathologic parameters (P> 0.05). The expression of AEG-1 was positively correlated with the expression of CD133 (r = 0.250, P = 0.027). Addition, retrieved data on TCGA implied co-occurrence of genomic alterations of AEG-1 and PPP6 c in glioblastoma. Our findin gs indicate that AEG-1 is positively correlated with CD133 and AEG-1 expression. It may play an important role in the progression of glioma and may serve as potential novel marker of chemoresistance and radioresistance.