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据Edelman提出的细胞产热的Na~+泵假说,机体产热的增加,在很大程度上与细胞膜Na~+泵活性的升高有关。阴虚和阳虚患者产热异常的表现,就可能伴有Na~+泵活性的改变。中药知母是一种滋阴泻火药,对阴虚患者具有良好的清热效果。菝葜皂甙元是知母提取物中的一个有效成份,已经证实它是Na~+、K~+-ATP酶的一种抑制剂,并且知母的清热作用的机理可能与菝葜皂甙元对Na~+、K~+-ATP酶的抑制有关。
According to the cell-heating Na~+ pump hypothesis proposed by Edelman, the increase in body heat production is, to a large extent, associated with an increase in the activity of the Na~+ pump in the cell membrane. The abnormal heat production in patients with yin deficiency and yang deficiency may be accompanied by changes in Na~+ pump activity. Chinese medicine Anemarrhenae is a kind of nourishing yin and purging medicine. It has good heat-clearing effect on patients with Yin deficiency. Anthraquinone is an active ingredient in Anemarrhenae Anemarrhenae extract. It has been proved to be an inhibitor of Na~+ and K~+-ATPases, and the mechanism of the heat-clearing effect of Anemarrhenae may be related to the anthraquinone aglycone. Inhibition of Na~+, K~+-ATPase is involved.