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柳氮磺胺吡啶(Sulfasalazine,SS)诱发肺疾病者罕见。本品最常见的副作用为胃肠道障碍、头痛、皮疹、肝炎等。英国文献曾报道19例SS诱发的肺疾病患者。现报告2例SS诱发的肺疾病。例1 男性,69岁。因Crohn病服用SS 500 mgtid。用药5年后出现劳力性呼吸困难;胸片示双肺基底肺间质浸润;肺功能试验显示气流量中度减少、弥散力减低。以后呼吸困难加重,并出现右侧胸膜炎性胸痛,胸片示气胸伴双侧广泛性肺间质浸润;胸水中含大量淋巴细胞,但无恶性肿瘤细胞,细菌培养亦阴性;血沉40mm/h。血气分析pH 7.48、PaCO_24.93 kPa、PaO_2 7.73 kPa。停用SS后半个月肺活检
Sulfasalazine (SS) -induced pulmonary disease is rare. The most common side effects of this product are gastrointestinal disorders, headache, rash, hepatitis and so on. 19 cases of SS-induced lung disease have been reported in British literature. Two cases of SS-induced lung disease are now reported. Example 1 male, 69 years old. SS 500 mgtid for Crohn’s disease. After 5 years of exertional exertional dyspnea; chest radiograph showed pulmonary interstitial lung infiltrates; pulmonary function tests showed a moderate decrease in air flow, reduced diffusion. Later dyspnea increased, and the right side of pleural inflammatory chest pain, chest X-ray showed bilateral bilateral extensive interstitial infiltration; pleural effusion contains a large number of lymphocytes, but no malignant tumor cells, bacterial culture also negative; ESR 40mm / h. Blood gas analysis pH 7.48, PaCO_24.93 kPa, PaO_2 7.73 kPa. Suspension of SS after the second half of lung biopsy