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目的：探讨CSFVWF含量变化及在不同部位脑梗死诊断中的临床价值。方法：应用双抗体夹心固相酶联免疫吸附法（ELISA）检测50例脑梗死患者和50例健康对照组CSF和血浆vWF含量。结果：ELISA法能敏感、快速、准确地检测CSFVWF的含量．病人组CSF和血浆VWF水平较对照组明显增高（P＜0．001），但在不同部位脑使死中CSFVWF含量变化可各有特点，而血浆VWF水平无明显改变。结论：CSFVWF含量的测定有助于不同部位脑梗死的临床鉴别诊断。CSF中VWF是脑血管内皮细胞受损的标志物，可作为缺血性脑血管病一个新的相对独立的危险因素。
Objective: To investigate the changes of CSFVWF content and the clinical value of different parts of cerebral infarction. Methods: The levels of vWF in plasma and CSF were measured in 50 patients with cerebral infarction and 50 healthy controls by double antibody sandwich enzyme-linked immunosorbent assay (ELISA). Results: The ELISA method could detect the CSFVWF content sensitively, rapidly and accurately. The levels of CSF and plasma VWF in patients were significantly higher than those in the control group (P <0.001). However, changes in CSFVWF content in different parts of the brain caused by death could have their own characteristics, but plasma VWF levels did not change significantly. Conclusion: The determination of CSFVWF contributes to the differential diagnosis of cerebral infarction in different sites. VWF in CSF is a marker of impaired cerebrovascular endothelial cells and may serve as a new, relatively independent risk factor for ischemic cerebrovascular disease.