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为在恢复神经再支配手术治疗喉返神经损伤所致的喉麻痹中,探索一种新的可避免神经误向支配的方法,采用非神经生物材料几了质管,桥接狗喉返神经干的缺损,并用自体神经移植作为对照组.术后5个月,组织学、组织化学和电生理等检测,显示两组动物的喉内肌皆获得神经再支配.实验组术侧声带较明显恢复了和健侧一致的内收和外展运动,甲杓肌(Thyroarytenoid,TAM)和环杓后肌(Posterior cricoarytenoid musdes,PCAM)也分别出现了相应的生理性自发肌电;对照组的术侧声带无明显的运动,TAM和PCAM则在呼气期和吸气期均出现不规则的持续密集自发肌电.提示几丁质桥接喉返神经干缺损可使其定向性再生,选择性支配喉内肌.
In order to restore the nerve re-dominating surgical treatment of recurrent laryngeal paralysis caused by recurrent laryngeal nerve paralysis, to explore a new method to avoid neural misdiagnosis, the use of non-biomaterials a few quality control, And the autograft was used as the control group.At 5 months after operation, histological, histochemical and electrophysiological examination showed that the inner thoracic muscles of the two groups of animals all achieved nerve re-dilation.The vocal cord in the experimental group recovered more obviously In contrast with contralateral adduction and outreach exercises, corresponding physiological spontaneous EMGs were also observed in Thyroarytenoid (TAM) and Posterior Cricoarytenoid Muscle (PCAM) No obvious movement, TAM and PCAM in the expiratory phase and inspiratory phase are irregular continuous dense electromyography. Tip chitin bridge recurrent laryngeal nerve trunk defect can make its directional regeneration, selective control of the throat muscle.