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目的:考察桉叶油对阿魏酸经皮吸收的促进作用。方法:进行体外透皮实验,分别以阿魏酸饱和溶液和加入1%辛酸癸酸聚乙二醇甘油酯(Labrasol○R)的阿魏酸饱和溶液为对照,考察在阿魏酸饱和溶液+1%Labrasol○R的基础上加入1%和2%的桉叶油对阿魏酸饱和溶液经皮吸收的促进作用。结果:桉叶油对阿魏酸经皮吸收(加入1%Labrasol○R的增溶剂)有促进作用,且具有剂量依赖性;Labrasol○R和桉叶油在促进阿魏酸经皮吸收方面有协同作用。结论:桉叶油可明显促进阿魏酸经皮吸收。
Objective: To investigate the promotion of eucalyptus oil on the percutaneous absorption of ferulic acid. Methods: The in vitro transdermal experiment was carried out. The ferulic acid saturated solution of 1% ferulic acid saturated solution and Labrasol ○ R caprylate were respectively used as the control. The ferulic acid saturated solution + 1% Labrasol ○ R based on the addition of 1% and 2% eucalyptus oil on the ferulic acid solution percutaneous absorption promotion. Results: Eucalyptus oil promoted the transdermal absorption of ferulic acid (solubilizer with 1% Labrasol ○ R) and had a dose-dependent manner; Labrasol ○ R and eucalyptus oil had the following effects in promoting the transdermal absorption of ferulic acid: Synergy. Conclusion: Eucalyptus oil can obviously promote the percutaneous absorption of ferulic acid.