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高催乳素血症可致卵巢功能紊乱,并导致不孕。然而,近年国外有若干报道少数本症伴存正常排卵周期与生育功能,引起人们注意。其循环中催乳素以生物活性较低的多聚型‘大’与‘大大’分子催乳素占主要成份,有人称作假高催乳素血症。通常使用胶层析方法检测到这类妇女循环中过量的多聚型‘大’与‘大大’分子催乳素成份。本文报告2例不孕妇女有高催乳素血症伴正常排卵周期。催乳素水平分别为133～165ng/ml和115～136ng/ml。胶层析结果显示其循环中‘大大’分子催乳素分别占83％及87％。例1同时合并有5.3× 4.7mm垂体微腺癌,经各项不孕原因检查,不孕并非高催乳素血症所致。
Hyperprolactinemia can cause ovarian dysfunction and lead to infertility. However, in recent years, there are several foreign reports of a few cases of this disease with normal ovulation cycle and fertility function, aroused people’s attention. Its cycle of prolactin bioactivity less poly congruent and ’big’ molecular prolactin as the main ingredient, some people called pseudo-hyperprolactinemia. Colloidal methods are commonly used to detect excess prolactin components in the circulation of these poly mers, large and large. This article reports 2 cases of infertile women with hyperprolactinemia with normal ovulation cycle. Prolactin levels were 133 to 165 ng / ml and 115 to 136 ng / ml, respectively. Gum chromatography showed that the circadian ’bulky’ prolactin molecules account for 83% and 87%, respectively. Case 1 also incorporates 5.3 × 4.7mm pituitary micro-adenocarcinoma, the reasons for infertility check, infertility is not caused by hyperprolactinemia.