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本文用改良凝集法和单向免疫扩散法对30例重肝患者及100名正常人和30例慢活肝患者检测了血浆纤维结合蛋白(Fibronectin,Fn),同时还测定了肝功能、C_3和Ig,其中21例重肝还测定了内毒素。血浆Fn正常水平为284.31±45.56μg/ml((?)±SD)和1∶30.64(几何均数)。重肝患者血浆Fn水平明显降低,与SB、PT、C_3和IgM显著相关,与内毒素血症的发生关系密切。动态观察血浆Fn水平有助于判断重肝患者的病情和预后。
In this study, fibronectin (Fn) and fibronectin (Fn) were detected by modified agglutination and unidirectional immunodiffusion in 30 patients with severe hepatitis and 100 normal controls and 30 patients with chronic liver failure. Liver function, C_3 and Ig, of which 21 cases of severe liver also measured endotoxin. Plasma Fn normal levels were 284.31 ± 45.56 μg / ml (± SD) and 1:30.64 (geometric mean). The levels of plasma Fn in patients with severe hepatitis were significantly lower, significantly correlated with SB, PT, C_3 and IgM, and closely related to the occurrence of endotoxemia. Dynamic observation of plasma Fn levels can help determine the severity of liver disease and prognosis.