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40例原发性高血压病患者分别口服常释型(A组,20例)和缓释型(B组,20例)硫氮草酮4周。A组服60mg3次/日,B组服90mg2次/日;总有效率分别为85.0％、90.0％,与治疗前比较均有明显的降压效果(P<0.01)。用放射免疫分析法测定A组治疗前后的血浆内皮素(ET)和血管紧张素Ⅱ(AⅡ)含量,服药前二者水平较对照组显著升高(P<0.01),与血压升高的程度均呈正相关;服药后二者水平均显著下降(P<0.01),但仍高于对照组(P<0.01)。ET和AⅡ的下降幅度也有明显的相关性(r=0.549 P<0.01)。提示ET和AⅡ在高血压发病中均起重要作用,硫酸草酮的降压作用可能与通过降低Ca~(2+)内流,拮抗ET和AⅡ的生物学效应有关。
Forty patients with essential hypertension were given oral administration of 20 mg of diazepam (group A, n = 20) and 20 mg of diltiazem for 4 weeks. The total effective rate was 85.0% and 90.0% in group A and 60 mg / day in group B and 90 mg / day in group B, respectively. There was a significant antihypertensive effect compared with those before treatment (P <0.01). The levels of plasma endothelin (ET) and angiotensin Ⅱ (AⅡ) in group A before and after treatment were measured by radioimmunoassay. The levels of ET and AⅡ in group A before and after treatment were significantly higher than those in control group (P <0.01) (P <0.01), but still higher than the control group (P <0.01). There was also a significant correlation between the decrease of ET and AII (r = 0.549 P <0.01). These results suggest that ET and AII play an important role in the pathogenesis of hypertension. The antihypertensive effect of H2SO4 may be related to reducing the Ca2 + influx and antagonizing the biological effects of ET and AII.