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人乳头状瘤病毒(HPV)对发生乳头状瘤有一定关系,已早被认识。因为自肿瘤中可测出HPV DNA。至1988年已有6篇文章提到在喉癌中曾测出过HPV_(6,11,16,30)四种DNA。由于分子生物学的发展。1989年日本Kiyabu提出一种用聚合酶链反应(PCR)的检测方法,检测了有淋巴结转移的喉鳞癌34例,发现此法对检测转移淋巴结中_(6b)及_(16)两种DNA有高度敏感性。声门癌9例,声门上癌23例,声门下癌2例。男30例,女4例。全部患者有吸烟史,且Brinkman指标都超过500。结果在总34例中,HPV_(16)DNA6例阳性占17.6%;HPV_(6b)DNA1例阳性占2.9%;声门癌9例中
Human papillomavirus (HPV) has a certain relationship to the occurrence of papilloma and has long been recognized. Because HPV DNA can be detected from the tumor. By 1988, there were 6 articles mentioning the detection of HPV_(6,11,16,30) DNA in laryngeal cancer. Due to the development of molecular biology. In 1989, Kiyabu of Japan proposed a detection method using polymerase chain reaction (PCR) to detect 34 cases of laryngeal squamous cell carcinoma with lymph node metastasis. This method was found to detect metastatic lymph nodes _(6b) and _(16). DNA is highly sensitive. There were 9 cases of glottic carcinoma, 23 cases of supraglottic carcinoma, and 2 cases of subglottic carcinoma. There were 30 males and 4 females. All patients had a history of smoking and the Brinkman index exceeded 500. Results Among the total 34 cases, HPV 16 DNA was positive in 17.6%; HPV 6b DNA was positive in 2.9%; glottic cancer was in 9 cases.