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脂联素(adiponectin)是由脂肪细胞分泌的一种特殊血浆蛋白,正常人体中血浆脂联素含量丰富。体外研究发现脂联素抑制各种细胞黏附分子的表达;细胞培养证实脂联素可抑制血管细胞及平滑肌的增殖,并抑制单核-巨噬细胞的迁移及向泡沫细胞的转化;动物实验发现脂联素基因缺陷小鼠动脉内膜明显增厚;临床研究发现肥胖、糖尿病、代谢综合征、冠心病患者血浆脂联素水平明显下降。种种迹象表明脂联素具有抗动脉粥样硬化的作用。
Adiponectin (adiponectin) is a special plasma protein secreted by fat cells, the normal human plasma adiponectin content is rich. In vitro study found that adiponectin inhibited the expression of various cell adhesion molecules; cell culture confirmed that adiponectin can inhibit the proliferation of vascular cells and smooth muscle and inhibit monocyte-macrophage migration and foam cell transformation; animal experiments found that Adiponectin gene-deficient mice significantly thicken the intima; clinical studies found that obesity, diabetes, metabolic syndrome, coronary heart disease patients with plasma adiponectin levels decreased significantly. There are indications that adiponectin has anti-atherosclerotic effect.