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目的对早期类风湿关节炎(RA)患者的血液检查指标进行分析,探讨抗环瓜氨酸钛抗体(抗CCP抗体)及类风湿因子(RF)的临床诊断价值。方法收集中国人民武装警察部队后勤学院附属医院呼吸-风湿门诊2015年6月-2016年6月诊治的早期RA患者50例为观察组,并选同期非RA患者50例为对照组。比较两组患者的抗CCP抗体、RF检测结果。结果观察组中抗CCP抗体阳性率为78.0%,RF阳性率为82.0%,二者联合检测阳性率为72.0%,分别优于对照组的6.0%、12.0%、2.0%;观察组联合检测的特异性为98.0%,高于抗CCP抗体的94.0%,高于RF的88.0%,差异均有统计学意义(P<0.05)。结论应用ELISA检测抗CCP抗体,可大大提高RA的检出率,在早期RA诊断中具有较高的特异性,临床价值较高,值得推广。
Objective To analyze the blood test indexes of patients with early rheumatoid arthritis (RA) and discuss the clinical value of anti-cyclocitrulline antibody (anti-CCP antibody) and rheumatoid factor (RF). Methods Fifty cases of early stage RA patients diagnosed and treated in Respiratory Rheumatology Clinic of the affiliated hospital of PLA Armed Police Forces between June 2015 and June 2016 were selected as the observation group and 50 cases of non-RA patients were selected as the control group. Anti-CCP antibody and RF test results of two groups were compared. Results In the observation group, the positive rate of anti-CCP antibody was 78.0% and the positive rate of RF was 82.0%. The positive rate of combined detection of the two drugs was 72.0%, which were respectively 6.0%, 12.0% and 2.0% Specificity was 98.0%, higher than 94.0% of anti-CCP antibody, higher than 88.0% of RF, the difference was statistically significant (P <0.05). Conclusion The detection of anti-CCP antibody by ELISA can greatly improve the detection rate of RA, which has high specificity in diagnosis of early RA and high clinical value, which is worthy of popularization.