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目的探讨康复新液对大鼠烧伤和家兔烫伤创面愈合的影响。方法 40只SD大鼠和24只家兔,雌雄各半,随机分为4组,分别为模型组、阳性对照组、康复新低剂量组及高剂量组。采用乙醇燃烧法建立大鼠皮肤深Ⅱ度烧伤模型、点状温热烫伤法建立家兔皮肤深Ⅱ度烫伤模型,模型组予0.9%氯化钠溶液、阳性对照组予磺胺嘧啶银乳膏、高剂量组予康复新原液、低剂量组予1/2康复新原液,均匀涂抹烧烫伤创面皮肤,每日3次,连续14天,观察各组不同时间创面愈合情况及病理组织学检查。结果高剂量组大鼠各时间点烧伤创面面积均明显小于模型组(P<0.05或P<0.01);给药第7天,低剂量组烧伤创面面积明显小于模型组(P<0.05)。家兔烫伤试验,康复新给药第10,14天,高剂量组、低剂量组烫伤创面面积明显小于模型组(P<0.05)。结论康复新液对促进大鼠皮肤烧伤、家兔皮肤烫伤创面愈合作用显著。
Objective To investigate the effect of Kangfuxin solution on burns and burns wound healing in rats. Methods Forty SD rats and 24 rabbits were randomly divided into 4 groups: model group, positive control group, low dose rehabilitation group and high dose group. The deep Ⅱ degree scald model of rat skin was established by ethanol combustion method. Deep scald scald model of rabbit skin was established by hot point scalding method. The model group was treated with 0.9% sodium chloride solution, the positive control group was given silver sulfadiazine cream, The high-dose group was given a new solution of rehabilitation. The low-dose group was given a new solution of 1/2 rehabilitation. The skin of the burn wounds was evenly applied three times a day for 14 consecutive days. The wound healing and histopathological examination were observed at different times. Results The burn wound area in high dose group was significantly smaller than that in model group at each time point (P <0.05 or P <0.01). On the 7th day after administration, burn wound area in low dose group was significantly smaller than that of model group (P <0.05). In scalded rabbits, the area of scalded wounds in high-dose group and low-dose group was significantly less than that in model group (P <0.05) on the 10th and 14th day after the rehabilitation. Conclusion Kangfuxin solution can promote the burn of the skin of rabbits and the burns of rabbits.