小鼠模型试验证明,体液免疫和细胞介导的免疫反应均参与了对兼性细胞内寄生的牛种布氏菌的保护性免疫反应。牛种布氏菌强毒株如2308号株,尽管存在宿主的免疫反应,仍然具有对牛或Balb/C小鼠产生慢性感染的能力。其作用机制不详,利用这一特性可区分强毒株和弱毒S19株,后者长期来一直用作牛的活免疫菌苗,并可从Balb/C Mouse model tests demonstrated that both humoral and cell-mediated immune responses are involved in the protective immune response to B. intracellularis in facultative cells. Brucella bovine strains such as strain 2308, despite their host immune response, still have the ability to chronically infect cattle or Balb / C mice. Its mechanism of action is unknown and this property can be used to distinguish virulent and attenuated S19 strains that have long been used as live vaccine for cattle and are available from Balb / C