高血压是心脑血管疾病的首要危险因素,严重威胁着人类的生命健康。生物肽能有效预防和治疗高血压,并且具有安全可靠、作用多靶点等特点。大量的研究表明生物肽存在多种降压作用机制,深入研究降压机制可为中药治疗高血压提供新思路。本文综述了近年来生物肽潜在的降压机制,并探索其定量构效关系,旨在为中药药效组分的研究以及相关药物设计和筛选提供理论指导。 Hypertension is the primary risk factor of cardiovascular and cerebrovascular diseases, which seriously threatens human life and health. Bio-peptide can effectively prevent and treat high blood pressure, and has the characteristics of safe and reliable, multi-target. A large number of studies have shown that there are a variety of bio-peptide antihypertensive mechanism, in-depth study of antihypertensive mechanism can provide new ideas for Chinese medicine treatment of hypertension. This review summarizes the potential mechanism of blood pressure reduction in recent years and explores its quantitative structure-activity relationship, aiming to provide theoretical guidance for the study of Chinese medicinal components and related drug design and screening.