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患者男,28岁,已婚。1990年4月因精神异常首次住院,诊断躁狂症.首选冬眠灵治疗,逐渐增药日量达750mg,用药10天因过敏而改用氟哌啶醇治疗日量达72mg,但改药后12天又出现过敏而停药。因减药及换药病情加重后用小剂量氯氮平100mg合并卡马西平0.4ng每日2次,用药后患者运动性兴奋及言语兴奋消失,睡眠明显增多。用药后24天精神状态恢复正常,自知力痊愈出院。氯氮平虽有强大的抗精神病作用对运动性兴奋及幻觉妄想
Male patient, 28 years old, married. April 1990 due to mental disorders for the first time hospitalized, the diagnosis of mania.Preferred winter sleep Ling treatment, the gradual increase in the daily dose of 750mg, 10 days due to allergy to haloperidol treatment of the daily amount of 72mg, but the drug 12 days there are allergies and withdrawal. Due to the reduction of drug and dressing disease aggravated with small doses of clozapine 100mg combined with carbamazepine 0.4ng 2 times a day after treatment, patients with exercise excitement and speech excitement disappeared, sleep increased significantly. The mental state returned to normal 24 days after treatment, healed and discharged. Although clozapine has a strong anti-psychotic effect on motor excitement and hallucinations