论文部分内容阅读
目的系统评价奥曲肽联合垂体后叶素治疗肝硬化上消化道出血的疗效和安全性。方法通过Pubmed、Cochane Library、Embase、CNKI、维普等数据库检索有关奥曲肽联合垂体后叶素治疗肝硬化上消化道出血的文献,采用改良Jadad量表进行质量评分,Rev Man5.3.1软件进行统计分析。结果共纳入16篇随机对照试验,Meta分析结果显示:奥曲肽联合垂体后叶素治疗肝硬化上消化道出血能够提高总有效率(RR=1.20,95%CI 1.09～1.33,P=0.0003),降低平均止血时间(MD=-15.12,95%CI-19.87～-10.36,P<0.00001),但不良反应等指标联合组与对照组比较差异无统计学意义(P>0.05)。结论奥曲肽联合垂体后叶素治疗肝硬化上消化道出血可明显提高治疗总有效率,但与不良反应等预后结局的关系尚不明确,且纳入文献质量不高,因此有必要开展此方面的高质量、大样本、多中心的随机对照试验。
Objective To evaluate the efficacy and safety of octreotide combined with pituitrin for the treatment of upper gastrointestinal bleeding in cirrhosis. Methods The literature about the effect of octreotide combined with vasopressin on cirrhosis and upper gastrointestinal bleeding was searched through Pubmed, Cochane Library, Embase, CNKI and VIP databases. The quality was assessed by modified Jadad scale and RevMan5.3.1 software was used for statistical analysis. Results A total of 16 RCTs were included in the meta-analysis. Meta-analysis showed that octreotide combined with pituitrin could improve the total effective rate (RR = 1.20, 95% CI 1.09-1.33, P = 0.0003) and lower The average hemostasis time (MD = -15.12,95% CI-19.87 ~ -10.36, P <0.00001), but there was no significant difference between the combination group and the control group (P> 0.05). Conclusions The combination of octreotide and pituitrin in the treatment of cirrhosis and upper gastrointestinal hemorrhage can obviously improve the total effective rate of treatment, but its relationship with the prognosis of adverse reactions is not yet clear, and the quality of the included literature is not high, so it is necessary to carry out this aspect of high Quality, large sample, multicenter randomized controlled trial.