随着分子生物学和基因工程学的进展,为了弥补电子起搏器的不足,生物起搏器应运而生.基因治疗作为构建生物起搏器的一个切实可行的方法,指通过载体将目的基因导入宿主并使其表达,以达到治疗的目的.而病毒载体是实现基因递送的前提条件,不同病毒载体在研究应用中均存在一定的优势和局限,现就生物起搏中常用的病毒载体(慢病毒、腺病毒和腺相关病毒)的结构特性以及在起搏中的应用选择做一综述.“,”With advances in the development of molecular biology and genetic engineering , biological pacemakers were created to compensate for the shortage of electronic pacemaker .Gene therapy is a feasible method to construct a biological pacemaker ,which means that the target gene is transfected and expressed to recover the cardiac function in host .Research has shown that virus vector is a prerequisite for gene delivery but has some advantages and limitations .In this paper ,we review the major viral vectors in the biological pacemaker ,including lentivirus,adenovirus and adeno-associated virus,their characteristics and applications .