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目的 研究增殖细胞核抗原(PCNA)在胃癌中的表达及临床意义。方法 应用免疫组织化学技术(SP法)检测50例胃癌组织中PCNA的表达变化与胃癌的生物学行为的关系。结果 PCNA表达与病人性别、年龄、肿瘤大小、组织学类型不相关(P>0.05),而与肿瘤浸润深度、淋巴结是否转移相关(P<0.05)。结论 PCNA检测可作为判断胃癌生物学行为的一个良好指标。
Objective To study the expression and clinical significance of proliferating cell nuclear antigen (PCNA) in gastric cancer. Methods Immunohistochemical technique was used to detect the relationship between the expression of PCNA in 50 cases of gastric cancer and the biological behavior of gastric cancer. Results There was no correlation between PCNA expression and patient’s gender, age, tumor size and histological type (P>0.05), but related to depth of tumor invasion and metastasis of lymph nodes (P<0.05). Conclusion PCNA detection can be used as a good indicator to judge the biological behavior of gastric cancer.