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目的探讨反映缺铁性贫血铁剂治疗有效的早期指标。方法2001-06~2004-07选择同济大学附属东方医院34例缺铁性贫血患者进行前瞻性观察,口服琥珀酸亚铁治疗前及治疗后第4天、第7天、第11天、第14天、第18天及第21天分别用Abbott细胞计数仪检测外周血红细胞计数(RBC)、血红蛋白质量浓度(Hb)、红细胞平均体积(MCV)和红细胞平均血红蛋白(MCH)。结果RBC、Hb、MCV及MCH平均值在第4天即见升高,以后继续逐步升高。第7天与治疗前测定的平均值相比,Hb(P=0.001)、MCV(P=0.008)升高有极显著意义,MCH升高有显著意义(P=0.016)。第4天时88.2%、88.2%和91.2%患者,第7天时全部患者的Hb、MCV及MCH均比治疗前升高。结论Hb、MCV、MCH可作为观察补铁疗效的方便敏感的指标。
Objective To investigate the early indicators that reflect the treatment of iron deficiency anemia. Methods From June 2001 to June 2004, 34 patients with iron deficiency anemia in Tongfang University Affiliated Dongfang Hospital were prospectively observed. Before oral administration of ferrous succinate and on days 4, 7, 11, 14 (RBC), hemoglobin concentration (Hb), mean corpuscular volume (MCV) and mean hemoglobin (MCH) of erythrocytes were detected by Abbott cytometer on day 18, day 18, Results The average values of RBC, Hb, MCV and MCH increased on the fourth day and continued to increase gradually thereafter. There was a significant increase in Hb (P = 0.001) and MCV (P = 0.008) on day 7 compared to the mean value measured before treatment, with a significant increase in MCH (P = 0.016). On the 4th day, 88.2%, 88.2% and 91.2% of the patients had Hb, MCV and MCH in all the patients on the 7th day than before treatment. Conclusion Hb, MCV and MCH can be used as convenient and sensitive indicators to observe the efficacy of iron supplementation.