四环素在临床上应用很广。近年来人们发现,四环素族抗菌素,尤其是四环素本身可引起严重的、甚至是致命的毒性反应,即肝、肾功能损害和急性胰腺炎。最近我们收治1例支气管扩张症合并肺炎患者,间断给予常规剂量四环素,竟引起严重的中毒性肝炎,经肝穿刺活检证实。此种情况国内甚少报道,今结合文献介绍如下,以引起临床医生注意。 Tetracycline is widely used in clinical practice. In recent years, it has been found that tetracycline antibiotics, especially tetracycline itself, can cause severe and even fatal toxic reactions, namely liver and renal dysfunction and acute pancreatitis. Recently, we admitted a case of bronchiectasis patients with pneumonia, intermittent routine dose of tetracycline, actually caused by severe toxic hepatitis confirmed by liver biopsy. This situation is rarely reported in the country, combined with the literature described below, to attract clinicians attention.