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多数梅毒患者经过规范驱梅治疗后,梅毒血清反应素滴度可转阴。但仍有部分患者梅毒血清反应素抗体滴度不能转阴且下降到某水平后不再改变,即梅毒血清固定。临床工作中,梅毒血清固定的治疗非常棘手,且其发病机制不明,多认为与机体免疫功能受到抑制有关,涉及T细胞亚群比例失衡、调节性T细胞表达异常、Th1/Th2型细胞因子的失衡及NK细胞活性下降等诸多因素。文中总结回顾国内外青霉素类、非青霉素类等多种治疗梅毒血清固定的疗效,及其发病机制的研究进展,并对未来研究的热点问题及发展趋势进行分析。
Most syphilis patients after standardized treatment of plum, syphilis serotonin titers can turn negative. But still some patients with syphilis serum antibody titer can not be negative and dropped to a certain level after no change, that is, syphilis serum. In clinical work, the treatment of syphilis serum is very tricky, and its pathogenesis is unknown, and more thought to be related to the inhibition of immune function, involving the imbalance of T cell subsets, abnormal expression of regulatory T cells, Th1 / Th2 type cytokines Imbalance and decreased NK cell activity and many other factors. The article reviews the clinical efficacy of penicillins and non-penicillin treatment of syphilis at home and abroad, and the research progress of its pathogenesis, and analyzes the hot issues and development trends in the future.