论文部分内容阅读
目的:探讨血清可溶性细胞表面分化抗原CD40配体(sCD40L)、脂联素水平与2型糖尿病并发急性冠脉综合征的关系及其临床意义。方法:采用ELISA检测62例2型糖尿病并发急性冠脉综合征患者、61例无并发症的2型糖尿病患者血清sCD40L和脂联素浓度,并以60例健康人作为对照。结果:2型糖尿病并发ACS组的血清sCD40L和FPG水平高于无并发症组及正常对照组(均P<0.01),而APN水平则显著降低;(P<0.01);DM并发ACS组血清sCD40L水平较DM无并发症组也显著升高(P<0.01),APN水平也显著降低(P<0.01);DM并发UA组血清sCD40L水平较DM并发AMI组升高(P<0.05),而血清adiponectin水平降低(P<0.05);血清sCD40L与APN水平呈显著负相关(r=-0.765,P<0.01),血清FPG与sCD40L、APN水平无相关关系(r=0.076,r=-0.116,均P>0.05)。结论:血清sCD40L、APN可能参与了2型糖尿病并发ACS的发病过程,可能成为ACS并发症的预测因子。
Objective: To investigate the relationship between serum soluble cell surface differentiation antigen CD40 ligand (sCD40L), adiponectin and type 2 diabetes mellitus complicated with acute coronary syndrome and its clinical significance. Methods: Serum levels of sCD40L and adiponectin in 62 patients with type 2 diabetes mellitus complicated with acute coronary syndrome and type 2 diabetes mellitus without complications were detected by ELISA, and 60 healthy controls were used as controls. Results: Serum levels of sCD40L and FPG in patients with type 2 diabetes complicated with ACS were significantly higher than those without complications and normal controls (all P <0.01), while the levels of APN were significantly decreased (P <0.01) The level of serum sCD40L in DM complicated with UA group was higher than that in DM complicated with AMI group (P <0.05), while the serum level of sCD40L (r = -0.765, P <0.01). No correlation was found between serum FPG and sCD40L and APN levels (r = 0.076, r = -0.116, all P <0.05). The levels of serum sCD40L and APN were negatively correlated P> 0.05). Conclusion: Serum sCD40L and APN may be involved in the pathogenesis of type 2 diabetes complicated with ACS and may be predictors of ACS complications.