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目的:观察注射用红花黄色素辅助治疗早期糖尿病肾病(diabetic nephropathy,DN)的临床效果。方法:选择2011年10月至2012年2月我院收治的早期DN患者86例,在患者知情同意的情况下随机分为对照组(n=42例)和观察组(n=44例),对照组采取西医常规治疗措施,观察组在上述治疗措施的基础上加用注射用红花黄色素治疗,治疗4周后,比较两组患者的实验室检查指标及临床疗效。结果:治疗4周后,观察组患者的白蛋白排泄率(UAER)、尿β2微球蛋白(β2-MG)、血肌酐(Scr)、血尿素氮(BUN)、血甘油三酯(TG)、血胆固醇(TC)、低密度脂蛋白(LDL)均显著低于对照组,差异均具有统计学意义(P<0.05);对照组治疗总有效率为85.7%,观察组治疗总有效率为97.7%,两组患者治疗总有效率比较,差异具有统计学意义(P<0.05),观察组优于对照组。结论:注射用红花黄色素治疗辅助治疗早期DN可有效其提高临床疗效。
Objective: To observe the clinical effect of injection of safflower yellow in the treatment of early diabetic nephropathy (DN). Methods: Totally 86 early DN patients admitted to our hospital from October 2011 to February 2012 were randomly divided into control group (n = 42) and observation group (n = 44) with informed consent. Control group to take conventional Western treatment, the observation group in the above treatment based on the addition of safflower yellow injection treatment, after 4 weeks of treatment, the two groups of patients compared laboratory tests and clinical efficacy. Results: After 4 weeks of treatment, the albumin excretion rate (UAER), urinary β2 microglobulin (β2-MG), serum creatinine (Scr), blood urea nitrogen (BUN), triglyceride (TG) , TC and LDL in the control group were significantly lower than those in the control group (P <0.05). The total effective rate in the control group was 85.7%. The total effective rate in the observation group was 97.7%. There was significant difference between the two groups in the total effective rate (P <0.05). The observation group was superior to the control group. Conclusion: The injection of safflower yellow dye adjuvant treatment of early DN can improve its clinical efficacy.