三苯氧胺柠檬酸盐(Tamoxifen Citrate)是一种非甾体抗雌激素类的抗癌新药。由于其结构中有C=C双键存在,就产生E型和Z型两种异构体。临床应用表明,Z型异构体对晚期乳癌及子宫膜癌有一定疗效,显示了抗雌激素作用.而E型具有雌激素作用。为此应严格控制E型异构体的含量。 异构体的分离较难,三苯氧胺又是个碱性离子化合物,更增加了分离定量的难度。本文采用反相 Tamoxifen Citrate is a non-steroidal anti-estrogen anti-cancer drug. Due to the presence of C = C double bonds in the structure, both E and Z isomers are produced. Clinical application shows that the Z isomer of advanced breast cancer and uterine cancer have a certain effect, showed anti-estrogen effect, while the E-type with estrogen. This should be strictly controlled E-type isomer content. Iso separation of the more difficult, tamoxifen is a basic ionic compound, but also increases the difficulty of separation and quantification. This article uses the reverse phase