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目的探讨亚临床甲状腺功能减退症(SCH)与非特异性免疫指标的相关性。方法选取SCH患者80例作为观察组,对照组为同期门诊甲状腺功能正常的健康体检者40例,分别检测患者促甲状腺激素(TSH)、血清白细胞介素-6(IL-6)、血清肿瘤坏死因子-α(TNF-α)及超敏C反应蛋白(hs-CRP),对数据进行分析。结果两组FT3、FT4差异均无统计学意义(均P>0.05)邓察组TSH、IL-6、TNF-α、hs-CRP均明显高于对照组,差异均有统计学意义(均P<0.01),TSH与IL-6、TNF-α及hs-CRP均呈正相关(均P<0.01)。结论 SCH可诱发IL-6、TNF-α、hs-CRP,使其浓度不同程度的升高而增加冠心病概率。
Objective To investigate the correlation between subclinical hypothyroidism (SCH) and nonspecific immune parameters. Methods Eighty patients with schizophrenia were enrolled as the observation group. The control group consisted of 40 healthy volunteers with normal thyroid function in the same period. Serum levels of thyroid stimulating hormone (TSH), serum interleukin-6 (IL-6), serum tumor necrosis Factor-α (TNF-α) and high-sensitivity C-reactive protein (hs-CRP), the data were analyzed. Results There were no significant differences in FT3 and FT4 between the two groups (all P> 0.05). The levels of TSH, IL-6, TNF-α and hs-CRP in the two groups were significantly higher than those in the control group <0.01). TSH was positively correlated with IL-6, TNF-α and hs-CRP (all P <0.01). Conclusion SCH can induce IL-6, TNF-α and hs-CRP, and increase the concentration of SCH to increase the probability of coronary heart disease.