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目的 :探讨腹腔内注入尿激酶 (UK) ,对渗出型结核性腹膜炎所致的腹腔内粘连和包裹性积液的影响。方法 :采用随机分组法将93例渗出型结核性腹膜炎分为治疗组 (A组48例 )和对照组 (B组45例 ) ,两组采用相同的化疗方案 ,抽腹水后均注入异烟肼 (INH)0 3、地塞米松10mg ,A组加入UK2万IU。结果 :腹腔内粘连发生率A组10 4 % ,B组28 9 % (P<0 05) ;包裹性积液发生率A组6 3 % ,B组20 % (P<0 05) ;平均给药次数A组5 4次 ,B组5 2次 (P>0 05)。结论 :腹腔内注入UK能有效降低渗出型结核性腹膜炎所致的腹腔内粘连和包裹性积液的发生 ,与对照组相比差异有显著性
Objective: To investigate the effect of intraperitoneal injection of urokinase (UK) on intraperitoneal adhesions and enveloping effusion caused by exudative tuberculous peritonitis. Methods: Ninety-three cases of exudative tuberculous peritonitis were divided into treatment group (48 cases in group A) and control group (group B, 45 cases). The same chemotherapy regimen was used in both groups. After ascites fluid was injected, Hydrazine (INH) 0 3, dexamethasone 10 mg, group A added UK2 million IU. Results: The incidence of intra-abdominal adhesions was 104% in group A and 28 9% in group B (P <0.05). Incidence of encapsulated effusion was 63% in group A and 20% in group B (P <0.05) The number of drugs was 54 in group A and 52 in group B (P> 0.05). Conclusion: Intraperitoneal injection of UK can effectively reduce the occurrence of intraperitoneal adhesions and encapsulated effusion caused by exudative tuberculous peritonitis, which is significantly different from the control group