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应用放射免疫分析方法，检测16只哮喘豚鼠一级传入系统和中枢内神经激肽A（NKA）的水平。与正常对照组（结状神经节62．82±11.09pg/gw.w，C7～C8段脊神经节53．78±12．63，T1～T2段脊神经节54．23±19．08，T3~T5段脊神经节50．53±14．23pg／gw．w;C7～T5段脊髓后角45．86±19．56，孤束核55．27±19．68pg/gw．w．和延髓腹侧浅层37.36±18．29pg/gw．w．）相比，哮喘豚鼠一级传入系统和中枢内（结状神经节83．81±15．23pg/gw．w．C7～C8段脊神经节72．11±17．16．T1～T2段脊神经节73．95±23．76，T3～T5段脊神经节70.53±14．23pg／gw．w，C7~T5段脊髓后角60.25±21．38pg／gww．孤束核71．36±18．76pg／gw．w和延髓腹侧线层49．58±20．19pg／gw．w．）NKA水平明显升高（P＜0．05）．这些结果提示，一级传入系统和中枢内的NKA可能参与哮喘的发病机制。
Radioimmunoassay was used to detect the levels of primary afferent system and central neurokinin A (NKA) in 16 asthmatic guinea pigs. Compared with the normal control group (nodular ganglion 62.82 ± 11.09pg / gw.w, C7 ~ C8 spinal ganglion 53.78 ± 12.63, T1 ~ T2 spinal ganglia 54.23 ± 19.08, T3 ~ T5 segment spinal ganglia 50.53 ± 14.23pg / gw.w; C7 ~ T5 spinal cord posterior horn 45.86 ± 19.56, solitary tract nucleus 55.27 ± 19.68pg / gw.w. and medulla ventral (37.36 ± 18.29 pg / gw.w) in the asthmatic guinea pigs (n = 83.81 ± 15.23pg / gw.w.C7 ~ C8 spinal ganglia 72 .11 ± 17.16.T1 ~ T2 segment spinal ganglia 73.95 ± 23.76, T3 ~ T5 segment of the spinal ganglia 70.53 ± 14.23pg / gw.w, C7 ~ T5 segment spinal cord posterior horn 60.25 ± 21.38pg / (71.36 ± 18.76pg / gw.w) and medulla oblongata (49.58 ± 20.19pg / gw.w) NKA levels were significantly increased (P <0.05). These results suggest that primary afferent system and central NKA may be involved in the pathogenesis of asthma.