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目的:探讨中青年2型糖尿病(T2DM)患者伴发勃起功能障碍(ED)与血管、神经和雄激素等因素的关系,为ED早期防治提供临床依据。方法:53例50岁以下男性T2DM患者按国际勃起功能指数-5(IIEF-5)评分分为ED组(IIEF评分≤21,n=28)和非ED组(NED组)(IIEF评分≥22,n=28),测定两组血脂、血糖、血清总睾酮(TT)、性激素结合蛋白(SHBG)、硫酸脱氢表雄酮(DHEA-S)、计算法游离睾酮(cFT)等指标,检查两组视网膜病变(DR)、大血管病变和周围神经病变(DPN)等并发症,比较两组各指标及并发症的差异。结果:两组年龄、糖尿病病程、体重指数、血压、血脂、血糖水平具有可比性(P>0.05),ED组DR发生率(39.3%)高于NED组(4.0%)(P<0.05),两组TT、DHEA-S、cFT水平及大血管病变和DPN发生率差异均无统计学意义(P>0.05)。结论:T2DM患者伴ED发生与DR关系密切,对合并DR的T2DM患者尤应早期关注其勃起功能。
Objective: To investigate the relationship between erectile dysfunction (ED) and vascular, neurological and androgen factors in middle-aged and young patients with type 2 diabetes mellitus (T2DM) and provide a clinical basis for early prevention and treatment of ED. Methods: Fifty-three T2DM patients under 50 years of age were divided into ED group (IIEF score ≤21, n = 28) and non-ED group (NED group) according to IIEF-5 score (IIEF score ≥22 , n = 28). The levels of blood lipid, blood glucose, total serum testosterone (TT), sex hormone binding protein (SHBG), DHEA-S and calculated free cortisol (cFT) Two groups of retinopathy (DR), macrovascular disease and peripheral neuropathy (DPN) and other complications were compared between the two groups of indicators and complications. Results: The incidence of DR was significantly higher in ED group (39.3%) than in NED group (4.0%) (P <0.05), while the duration of diabetes, body mass index, blood pressure, The TT, DHEA-S, cFT levels and the incidence of macrovascular disease and DPN in both groups showed no significant difference (P> 0.05). Conclusion: The incidence of ED in patients with T2DM is closely related to DR. Erectile function should be paid more attention to in patients with T2DM with DR.