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目的研究药物AB0315在大鼠各肠段吸收的药代动力学特征。方法采用大鼠在体肠段灌流实验装置,利用高效液相色谱法和紫外分光光度法分别测定肠循环液中药物AB0315和酚红的含量。结果药物AB0315在十二指肠、空肠、回肠、结肠的吸收速率常数分别为0.790 2、0.625 3、0.681 2、0.832 4 h-1;在不同药物浓度40、80、250μg/mL小肠的吸收速率常数分别为0.575 4、0.719 1、0.845 5 h-1;在不同pH值(4.0、6.5、7.4)时的吸收速率常数分别为0.7422、0.612 7、0.562 8 h-1。结论药物AB0315在大鼠小肠全肠段均有吸收,并且药物的吸收呈一级动力学,吸收机制为被动转运。
Objective To study the pharmacokinetics of AB0315 absorbed in various intestine of rats. Methods Rat intestine perfusion experimental apparatus was used to determine the contents of AB0315 and phenol red in intestinal fluid by HPLC and UV spectrophotometry respectively. Results The absorption rate constants of drug AB0315 in the duodenum, jejunum, ileum and colon were 0.790, 2.0625 3, 0.681, 2.0832 4 h-1, respectively. The absorption rates of small intestine at different drug concentrations of 40, 80 and 250μg / mL The constants were 0.575 4,0.719 1,0.845 5 h-1, respectively. The absorption rate constants at different pH values (4.0, 6.5, 7.4) were 0.7422, 0.612 7 and 0.562 8 h -1, respectively. Conclusion The drug AB0315 is absorbed in the intestine of intestine of rats and its absorption is in first order kinetics. The absorption mechanism is passive.