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目的评估准分子激光削融术（ＰＲＫ）后局部滴用艾氟龙（ｆｌｕｏｒｏｍｅｔｈｏｌｏｎｅ，ＦＭＬ）或地塞米松滴眼液（ｄｅｘａｍｅｔｈａｓｏｎｅ，ＤＥＸ）治疗后皮质类固醇性高眼压、角膜雾浊及屈光回退的发生率。方法追踪观察了ＰＲＫ治疗的１７７例患者（３４１眼）。患者自上皮愈合日始，随机分为滴０．１％艾氟龙或０．２５％地塞米松组。药物使用４次／ｄ，共１个月；从第２月始逐月每日减少１滴，总疗程４个月。随访时间分别在１０ｄ，１、２、３、４月。结果ＰＲＫ术后４月，皮质类固醇性高眼压发生率艾氟龙组为１４．８％，地塞米松组为３２．１％，差异有显著性（Ｐ＜０．０１）。角膜雾浊和屈光回退在两组间基本相似（Ｐ＞０．０５）。结论ＰＲＫ术后使用艾氟龙可有效降低皮质类固醇性高眼压的发生率，但对减轻角膜雾浊，防止屈光回退的效果两药相同。
Objective To evaluate the effects of topical drops of corneal ophthalmoplegia and corneal ophthalmoplegia after focal drip with fluorometholone (FML) or dexamethasone eye drops (DEX) after excimer laser ablation (PRK) The incidence of refractive regression. METHODS: A total of 177 patients (341 eyes) with PRK were followed up. Patients were randomly divided into 0.1% dexamethasone or 0.25% dexamethasone group, starting from the day of epithelial healing. Drug use 4 times / d, a total of 1 months; from the first 2 months a month by 1 drop daily, the total course of 4 months. Follow-up time was 10d, 1, 2, 3, 4 months. Results In 4 months after PRK, the incidence of corticosteroid-induced ocular hypertension was 14.8% in the Efron group and 32.1% in the dexamethasone group (P <0.01). Corneal haze and refractive regression were similar between the two groups (P> 0.05). Conclusions Use of efloxacin after PRK can effectively reduce the incidence of corticosteroid-induced ocular hypertension, but it is the same for reducing corneal haze and preventing refractive regression.