目的：了解低剂量电离辐射与镉之间是否存在交叉适应性反应。方法：孕第９天小鼠在整体条件下，全身受低剂量１、２、４、８ｃＧｙ６０Ｃｏγ射线照射，４ｈ后给致畸剂量镉４ｍｇ／ｋｇ，观察胚胎细胞染色体畸变率。结果：１、２、４、８ｃＧｙ６０Ｃｏγ射线，均能诱导胚胎细胞对镉４ｍｇ／ｋｇ的细胞遗传损伤的耐受性。结论：首次证明低剂量电离辐射可诱导出胚胎细胞对镉的细胞遗传交叉适应性反应 Objective: To understand whether cross-adaptive reactions exist between low-dose ionizing radiation and cadmium. Methods: On the 9th day of gestation, the whole body was exposed to 1, 2, 4, 8 cGy60Coγ ray and the teratogenic dose of cadmium 4 mg / kg 4 h later. The chromosome aberration rate of embryonic cells was observed. Results: 1, 2, 4, 8 cGy60Coγ ray could induce the tolerance of embryonic cells to cytogenetic damage of cadmium 4mg / kg. CONCLUSIONS: It was first demonstrated that low dose ionizing radiation induced a cytogenetic cross-adaptation of embryonic cells to cadmium