目的:研制剂型更适合治疗口腔溃疡的双层膜药物制剂。方法:通过预试验和L9(33)正交试验,筛选出适宜的口腔溃疡双层膜处方,用匀浆流延成膜法制成双层膜剂并进行相关指标的测定。结果:以2.5%乙基纤维素无水乙醇液作为空白隔离层,1.5%的壳聚糖和2.0%的明胶以1∶1配比作为药膜层得到的双层膜剂,外观性状及性能良好。结论:该制备工艺简便、易行,可用作复方龙血竭口腔溃疡双层膜的制备。 OBJECTIVE: To develop a bilayer membrane drug formulation that is more suitable for treating oral ulcer. Methods: By the pre-test and L9 (33) orthogonal test, the appropriate oral ulcer bilayer membrane prescription was screened, the bilayer membrane agent was prepared by the homogenization cast film method and the related indexes were determined. Results: The double-layer filming agent with 2.5% ethylcellulose anhydrous ethanol solution as the blanket, 1.5% chitosan and 2.0% gelatin as the drug film layer, the appearance and properties good. Conclusion: The preparation process is simple and easy to use, which can be used as a preparation for the oral ulcer double layer membrane of compound Dragon’s blood.