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随着生物工程技术的发展,特别是合成肽的工业化生产给临床治疗带来了极大的好处。但肽穿透生物屏障能力差而且生物半衰期短,这就影响了其药理学作用的发挥。粘膜给药及透皮吸收等方法有效地促进了肽及蛋白的生物利用度。特别是由于乳酸-羟基乙酸共聚物(以下简称PLGA)的生物重吸收性,用PLGA作药物包裹材料既能增加药物的稳定性,又有利于制成生物可降解型缓释制剂,所以本文选用PLGA为囊材,使其与肽类药物共溶于二氯甲烷,用滴加硅油的方法使成相分离而达到囊化的目的。
With the development of bioengineering technology, especially industrialized production of synthetic peptides has brought great benefits to clinical treatment. However, the ability of the peptide to penetrate the biological barrier is poor and the biological half-life is short, which affects its pharmacological effects. Mucosal administration and transdermal absorption and other methods effectively promoted the bioavailability of peptides and proteins. In particular, due to the bioabsorbability of lactic acid-glycolic acid (PLGA), the use of PLGA as a drug-encapsulating material can not only increase the stability of the drug, but also facilitate the preparation of a biodegradable sustained-release preparation. Therefore, PLGA as a capsule material, making it co-dissolved with the peptide drugs in methylene chloride, with a drop of silicone oil into the phase separation method to achieve the purpose of encapsulation.