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目的 观察托吡酯治疗小儿难治性癫(?)疗效、用药方法及副反应。方法 采用开放性方法对31例小儿难治性癫(?)患者进行单用或加用托吡酯治疗。观察其疗效及副反应。结果 托吡酯治疗小儿难治性癫(?)总有效率67.7％。38.7％患儿停止发作,对部分性发作疗效较好。其他类型发作亦有一定疗效。平均有效剂量为(4.0±1.8)mg·kg-1·d-1。副反应主要为体重减轻(16例,56.6％),神经系统症状,少汗或无汗,皮疹等,结论 托吡酯对小儿难治性癫(?)有良好疗效。
Objective To observe the efficacy, topical treatment and side effects of topiramate in refractory epilepsy in children. Methods A total of 31 children with refractory epilepsy (?) Were treated with topiramate alone or with open-label method. Observe its efficacy and side effects. Results Topiramate treatment of pediatric refractory epilepsy (?) The total effective rate was 67.7%. 38.7% of children stop seizures, the partial seizures better. Other types of attacks also have some effect. The average effective dose was (4.0 ± 1.8) mg · kg-1 · d-1. The main side effects were weight loss (16 cases, 56.6%), nervous system symptoms, little or no sweat, rash and so on. Conclusion Topiramate had a good effect on refractory epilepsy in children.