In traditional viewpoint,excitatory modulation always promotes neural firing activities.On contrary,the negative responses of complex bursting behaviors to excitatory self-feedback mediated by autapse with time delay are acquired in the present paper.Two representative bursting patterns which are identified respectively to be “Fold/Big Homoclinic”bursting and “Circle/Fold cycle” bursting with bifurcations are studied.For both burstings,excitatory modulation can induce less spikes per burst for suitable time delay and strength of the self-feedback/autapse,because the modulation can change the initial or termination phases of the burst.For the former bursting composed of quiescent state and burst,the mean firing frequency exhibits increase,due to that the quiescent state becomes much shorter than the burst.However,for the latter bursting pattern with more complex behavior which is depolarization block lying between burst and quiescent state,the firing frequency manifests decrease in a wide range of time delay and strength,because the duration of both depolarization block and quiescent state becomes long.Therefore,the decrease degree of spike number per burst is larger than that of the bursting period,which is the cause for the decrease of firing frequency.Such reduced bursting activity is explained with the relations between the bifurcation points of the fast subsystem and the bursting trajectory.The present paper provides novel examples of paradoxical phenomenon that the excitatory effect induces negative responses,which presents possible novel modulation measures and potential functions of excitatory self-feedback/autapse to reduce bursting activities.