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目的探讨瑞芬太尼用于肝癌手术麻醉的效果。方法抽取我院于2013-02-2015-03收治的肝癌手术患者84例作为临床研究对象。随机分组:对照组42例,采用芬太尼、丙泊酚进行诱导,使用异氟醚、阿曲库铵、丙泊酚维持麻醉;观察组42例,采用瑞芬太尼和丙泊酚进行诱导与维持麻醉。比较两组患者的麻醉效果。结果观察组患者在术前、插管即刻、术中牵拉、拔管即刻四个时间点的血流动力学变化幅度较小,比较无统计学意义,P>0.05;对照组在以上四个时间点的血流动力学变化幅度较大,比较具有统计学意义,P<0.05。观察组患者的自主呼吸恢复时间、睁眼时间、拔管时间均明显短于对照组,OAAS评分明显高于对照组,结果比较具有明显差异性,P<0.05。两组患者的手术时间、肝门阻断时间、失血量比较无明显差异性,P<0.05。结论瑞芬太尼在肝癌手术麻醉中的应用效果良好,值得推广使用。
Objective To investigate the effect of remifentanil on liver cancer surgery. Methods Totally 84 patients with hepatocellular carcinoma admitted in our hospital from February 2013 to February 2015 were selected as the clinical study subjects. Randomly divided into groups: control group of 42 cases, the use of fentanyl, propofol induction, the use of isoflurane, atracurium, propofol to maintain anesthesia; observation group, 42 patients were treated with remifentanil and propofol Induce and maintain anesthesia. The effects of anesthesia in two groups were compared. Results In the observation group, the changes of hemodynamics at preoperative, immediate intubation, intraoperative traction and immediate extubation were small, with no statistical significance (P> 0.05). In the control group, Time point of hemodynamic changes in a larger, more statistically significant, P <0.05. The spontaneous respiratory recovery time, open-eye time and extubation time in the observation group were significantly shorter than those in the control group, and the OAAS score was significantly higher than that in the control group. The results showed significant differences (P <0.05). There was no significant difference between the two groups in operation time, hilar blocking time and blood loss, P <0.05. Conclusion Remifentanil has a good effect in surgical operation of liver cancer and is worth promoting.