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目的对制备的左旋盐酸苯环壬酯鼻腔喷雾剂进行局部安全性评价。方法以蟾蜍上颚黏膜纤毛为模型考察纤毛毒性,以大鼠鼻黏膜形态学检查评价局部刺激性。结果左旋盐酸苯环壬酯鼻喷剂纤毛毒性及对局部刺激性均较小。结论左旋盐酸苯环壬酯鼻喷剂局部用药较安全,具有良好的应用前景。
OBJECTIVE To evaluate the safety of the preparation of levonorhenate hydrochloride nasal spray. Methods The ciliary toxicity of Toad palate mucosa cilia was investigated. The nasal mucosa morphology was used to evaluate the local irritation. Results L-phencynonate nasal spray ciliated toxicity and local irritation are small. CONCLUSIONS: Topical administration of levonorbate propionate nasal spray is safe and has good application prospect.