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糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)是糖尿病常见的慢性并发症之一,可累及感觉、运动及自主神经。周围神经受损后导致神经变性、坏死及功能丧失严重影响患者的生活质量,如何促进神经纤维的修复再生是近年来研究的热点。雪旺细胞(Schwann cells,SCs)是形成周围神经髓鞘的主要胶质细胞[1],其在周围神经修复再生中的作用引起学者的广泛关注。高糖状态易造成周围神经轴突萎缩、
Diabetic peripheral neuropathy (DPN) is one of the common chronic complications of diabetes. It can affect sensory, motor and autonomic nerves. Peripheral nerve damage leading to neurodegeneration, necrosis and loss of function seriously affect the quality of life of patients, how to promote the repair of nerve fiber regeneration in recent years, research hot spots. Schwann cells (SCs) are the main glial cells that form the peripheral nerve myelin [1], and their role in the repair and regeneration of peripheral nerves has drawn the attention of scholars. High sugar status easily lead to peripheral nerve axonal atrophy,