目的探讨细胞色素c在妊娠高血压综合征发病中的作用。方法取妊高征患者和正常健康产妇产后胎盘组织,用改良的张均田法测定组织中细胞色素c含量。结果重度妊高征组胎盘组织细胞色素c含量显著低于中度妊高征组(P<0.05);重度和中度妊高征组胎盘组织细胞色素c含量均显著低于正常组(P<0.05)。结论妊高征妇女胎盘组织细胞色素c含量明显低于正常孕妇,提示妊高征发病机制中有能量代谢传递障碍,线粒体能量产生异常参与妊高征发病过程。 Objective To investigate the role of cytochrome c in the pathogenesis of pregnancy induced hypertension. Methods The placental tissue of postpartum patients with PIH and normal healthy maternal postpartum were collected. The content of cytochrome c in the tissue was determined by modified Zhangsuntian method. Results The content of cytochrome c in placenta of severe PIH group was significantly lower than that in moderate PIH group (P <0.05). The content of cytochrome c in placenta of severe and moderate PIH group was significantly lower than that of the normal group (P < 0.05). Conclusions The content of cytochrome c in placenta of PIH women is significantly lower than that in normal pregnant women, suggesting that there is obstacle of energy metabolism in the pathogenesis of PIH. Abnormality of mitochondrial energy is involved in the pathogenesis of PIH.