自Besedovsky,提出神经-内分泌-免疫调节网学说以来,对这一网络的研究取得了很大进展。与此同时,另一极其活跃的领域——内源性阿片样肽(Opioid peptides,简称OP)的研究亦迅猛发展,不仅阐明了它们在脑内的分布、含量、代谢、神经通路及其相应的阿片受体(OP.R),而且指出了OP可能为一种重要的调质参与循环、呼吸、体温、疼痛感 Since Besedovsky proposed the neuro-endocrine-immune regulatory network theory, great progress has been made in this network. In the meantime, another extremely active field, the research on endogenous opioid peptides (OPs), is also rapidly developing, not only clarifying their distribution, content, metabolism, neural pathways and their corresponding Opiate receptor (OP.R), and pointed out that OP may be an important quenching involved in the cycle, breathing, body temperature, pain