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目的 探讨体外受精 胚胎移植 (IVF ET)中 ,在低回收卵数患者中进行囊胚培养和移植是否能改善IVF结局。方法 回顾分析 2 0 0 0年 1月至 2月在我室行IVF治疗的 5 9例患者的临床资料。其中 2 1例行囊胚培养 (囊胚组 ) ,在受精后第 5天移植 ;另 3 8例行常规的第 2天胚胎移植 (对照组 )。比较分析两组患者的临床结局。结果 囊胚组平均取卵数 ( 6 6± 2 8)个 ,临床妊娠率为 4 3 % ,分娩率 3 8% ;对照组平均取卵数 ( 6 9± 3 7)个 ,临床妊娠率为 3 7% ,分娩率 2 9% ,两组比较 ,差异无显著性 (P >0 0 5 )。囊胚组无一例出现高序多胎 ,对照组出现 1例 3胎 ,1例 5胎。结论 在IVF ET中 ,对低回收卵数患者进行囊胚培养和移植与常规第 2天移植相比 ,并不会显著提高妊娠率 ,但却可以在不降低妊娠率的情况下 ,减少多胎的出现。
Objective To investigate whether IVF ET can improve IVF outcome in blastocysts and transplant in patients with low egg count during IVF ET. Methods The clinical data of 59 patients who underwent IVF in our department from January to February in 2000 were retrospectively analyzed. Among them, 21 cases were cultured in blastocysts (blastocysts group), and were transplanted on the fifth day after fertilization. The other 38 cases were routinely transplanted on the second day (control group). Comparative analysis of two groups of patients with clinical outcomes. Results The average number of oocytes retrieved in the blastocyst group was (66 ± 2 8), the clinical pregnancy rate was 43% and the delivery rate was 38%. The average number of oocytes retrieved in the control group was (69 ± 37) 3 7% and delivery rate 29%. There was no significant difference between the two groups (P> 0.05). None of the blastocyst group presented with high-order multiple births, one case of 3-fetus and one case of 5-fetuses in the control group. CONCLUSIONS: In IVF ET, blastocyst culture and transplantation in patients with low egg recovery did not significantly improve pregnancy rates compared to routine day 2 transplantation, but could reduce multiple pregnancies without reducing pregnancy rates appear.