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多巴胺(DA)不仅为肾上腺素及去甲肾上腺素前体,而且可作为内源性生理活性物与各种功能有关。即:DA在中抠神经系统内神经末端释放,作为神经传递物,作用于神经未梢通过交感神经未端、肾上腺髓质、肾小管细胞释出,具有调节血压、体液及内分泌机能。肾DA对血压及体液调节作用主要包括①抑制肾交感神经未端NA释放。②抑制肾上腺髓质儿茶酚胺释放。③肾血管扩张,肾血流量增大引起钠利尿,④抑制肾上腺皮质分泌醛固酮引起钠利尿产生降压作用,此外分布全身血管床的交感神经末端释
Dopamine (DA) is not only adrenergic and norepinephrine precursors, but also serves as an endogenous physiologically active substance with a variety of functions. Namely: DA pull in the nerve endings in the nervous system release, as a neurotransmitter, acting on the nerve tip through the sympathetic nerve end, adrenal medulla, tubular cells release, with regulation of blood pressure, body fluids and endocrine function. Kidney DA on blood pressure and humoral regulation mainly include ① inhibition of renal sympathetic NA NA release. ② inhibition of adrenal medulla catecholamine release. ③ Renal dilatation, renal blood flow caused by increased sodium diuresis, ④ inhibit the secretion of aldosterone adrenal cortex caused by sodium diuretic antihypertensive effect, in addition to the distribution of systemic vascular bed sympathetic release