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为探讨bc1-2、p53在乳腺癌中表达的关系及意义。应用构缘酸—ABC—免疫组化法，对87例浸润性乳腺癌石蜡包理组织进行检测。结果：bc1－2＋／p53＋13例（14．94％），bc1－2—／P53—9例（10．34％），bc1－2＋／p53—42例（48．28％），bcl－2—／p53＋23例（26，44％），bcl－2和p53表达率之间呈明显负相关性（P＜0.01）。bcl－2—／p53十与bc1-2＋／p53—表达表型比较，分化差，核分裂多，淋巴结转移，复发，脏器转移，生存期＜5年，ER、PR阴性，PCNA强表达请参数中，差异均有显著性意义（P＜0．01），bc1-2＋／p53＋比bc1-2—／p53—表达表型分化差（P＜0．05）。提示：bc1－2和p53蛋白表达表型与浸润性乳腺癌的预后间存在着密切联系，以bc1－2＋／P53—为最佳，bc1－2—／P53＋为最差，另两种表型介于中间，但bc1-2—／P53—似较bc1－2＋／P53十为佳。bc1－2、p53蛋白表达和乳腺癌坏死之间无明显相关性。
To explore the relationship between the expression of bcl-2 and p53 in breast cancer and its significance. Paraffin-embedded tissues from 87 cases of invasive breast cancer were detected by constitutive acid-ABC-immunohistochemistry. Results: bc1-2+/p53+13 cases (14.94%), bc1-2-/P53-9 cases (10.34%), bc1-2+/p53-42 cases (48.28%), bcl-2- /p53+23 cases (26,44%) showed a significant negative correlation between bcl-2 and p53 expression rates (P<0.01). Differences in bcl-2/p53/bc1-2+/p53- expression phenotypes: Poor differentiation, multiple mitoses, lymph node metastasis, recurrence, organ metastasis, survival <5 years, ER, PR negative, strong PCNA expression. Parameters The difference was significant (P<0.01), and bc1-2+/p53+ had poorer differentiation than the bc1-2-/p53-expressing phenotype (P<0.05). It is suggested that there is a close relationship between the expression of bcl-2 and p53 protein and the prognosis of invasive breast cancer, with bc1-2+/P53- being the best and bc1-2-/P53+ being the worst, and the other two phenotypes. In the middle, but bc1-2-/P53-like better than bc1-2+/P53. There was no significant correlation between bcl-2, p53 protein expression and breast cancer necrosis.