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在卵巢癌诊断中,恶性风险指数综合了绝经状态、超声形态及血清CA125这3种高危因素,弥补了单项指标的不足,提高了诊断的敏感性和特异性。但仍有一些不足和滞后,需进一步改良且具有很大的改良空间。适当增加新的有意义的肿瘤标志物,如人附睾蛋白、间皮素、骨桥蛋白等,可与血清CA125互补,提高卵巢癌检出率;合理引入超声诊断的新指标,如阻力指数、搏动指数等,并结合遗传、环境等易感因素及患者临床症状,可提高恶性风险指数诊断效能,检出更多的早期卵巢癌。
In the diagnosis of ovarian cancer, the malignant risk index combines menopausal status, ultrasound morphology and serum CA125 these three risk factors to make up for the lack of a single indicator to improve the diagnostic sensitivity and specificity. However, there are still some shortcomings and lags behind, which require further improvement and great room for improvement. Appropriate to add new meaningful tumor markers, such as human epididymis protein, mesothelin, osteopontin, etc., can complement with serum CA125 to improve the detection rate of ovarian cancer; rational introduction of new diagnostic criteria for ultrasound, such as resistance index, Pulsatility index, etc., combined with genetic, environmental and other susceptibility factors and clinical symptoms of patients, can improve the diagnostic performance of malignant risk index, detect more early ovarian cancer.