论文部分内容阅读
目的分析破伤风疫苗免疫对不同性别和年龄段供血浆者抗-TT效价变化,为提高抗-TT高效价血浆采集量提供参考依据。方法对符合规定的志愿供血浆者按不同年龄段分组,以相同的疫苗剂量和免疫程序进行免疫。采用ELISA定量检测供血浆者抗-TT效价水平,将抗-TT效价≥8IU/ml的供血浆者列为采集特免血浆对象。结果不同年龄段供血浆者组别间相同剂量疫苗和免疫程序产生高效价抗-TT的比率比较差异明显;21~35岁组产生高效价的比率明显高于36~45岁组,46~55岁组产生高效价比例最低,而且年龄小的抗-TT高效价持续时间较年龄大的长。结论采用40IU吸附破伤风疫苗,0、4、4周程序免疫,38%的供血浆者可获得高效价抗-TT原料血浆,各年龄段供血浆者的破伤风抗体水平均能够达到保护的浓度。
Objective To analyze the change of anti-TT titer of tetanus vaccine for blood plasma of different gender and age, and to provide a reference for improving anti-TT high titer plasma collection. Methods The volunteers who meet the requirements were divided into groups according to different age groups and immunized with the same dose of vaccine and immune procedure. Anti-TT titers were quantitatively detected by ELISA, and plasma donors with anti-TT titers> 8IU / ml were included in the study. Results The ratio of high titer anti-TT to the same dosage of vaccine and immunization program of blood plasma in different age groups was significantly different. The ratio of high titer in 21-35 age group was significantly higher than that of 36-45 age group The oldest group produced the lowest titer of high titer, and the younger the anti-TT titer lasts longer than the older ones. Conclusion 40IU tetanus toxoid vaccine was used to immunize at 0, 4, and 4 weeks. 38% of plasma donors were given high titer of anti-TT raw plasma. The tetanus antibody levels of all age groups were able to reach the protection level .