自“多莉”诞生以来,在全世界掀起了一场体细胞克隆的浪潮,许多体细胞克隆动物,如小鼠、山羊、牛、猪等纷纷问世。围绕体细胞克隆的供体细胞周期问题,学术界存在两种不同的观点,一是Wilmut等认为体细胞必须经过休眠处理,使细胞停滞在G0/G1期,或者采用以G0/G1期为主的活体细胞作为供体,这是克隆成功的关键,这一方面的报道已有很多。第二是Cibelli等认为不必对细胞作 Since the birth of Dolly, a wave of somatic cloning has been set off in the world. Many somatic cloned animals such as mice, goats, cattle and pigs have come out in succession. There are two different viewpoints around the donor cell cycle in somatic cell cloning. One is that Wilmut et al. Think that somatic cells must be put under dormancy to stop the cells in G0 / G1 phase or take G0 / G1 phase as the main phase Of living cells as a donor, which is the key to the success of the cloning, there are many reports on this. The second is that Cibelli et al