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萸冰制剂是由华佗再造丸中主药吴茱萸与冰片组成。根据硝酸甘油、NO/NOS、偏头痛的内在联系,文章利用硝酸甘油型实验性偏头痛动物模型,并用硝酸还原酶法测定其血液中的NO/NOS含量。结果表明:硝酸甘油实验性偏头痛大鼠血清中NO/NOS的含量明显增强,萸冰制剂能明显降低偏头痛大鼠血清中NO/NOS的含量,且降低NO/NOS含量的作用明显优于西药阳性组(麦角胺咖啡因)和中药阳性组(正天丸),与模型组比较有显著或极显著差异。提示:萸冰制剂具有治疗实验性偏头痛动物模型的作用。
Fructus ice preparation is made of Huacha re-shot pills in the main drug Evodia and borneol composition. According to the intrinsic relationship between nitroglycerin, NO / NOS and migraine, this article uses nitroglycerin experimental migraine animal model and uses nitrate reductase method to determine the NO / NOS content in blood. The results showed that nitroglycerin migraine rats serum NO / NOS content was significantly enhanced, ictrinic preparations can significantly reduce the migraine rat serum NO / NOS content, and reduce the role of NO / NOS content was significantly better than Western medicine positive group (ergotamine caffeine) and Chinese medicine positive group (Zheng Tian Wan), compared with the model group, there are significant or very significant differences. Tip: Fructus icicles has the effect of treating experimental migraine animal model.