慢性阻塞性肺疾病(COPD)是一种具有气流受限特征的疾病,气流受限不完全可逆、进行性发展,与肺部对有害气体或颗粒的异常炎症反应有关。气道炎症、氧化/抗氧化失衡、蛋白酶/抗蛋白酶失衡均在COPD发病中起重要作用,但其气流受限的分子机制仍未阐明。近年来,蛋白酶/抗蛋白酶失衡与COPD发病机制的研究有很大进展,本文就此作一综述。 Chronic obstructive pulmonary disease (COPD) is a condition characterized by airflow limitation, which is not fully reversible and progressive development of air flow, and is related to the abnormal inflammatory response to noxious gases or particles in the lungs. Airway inflammation, oxidative / antioxidant imbalance, protease / protease imbalance play an important role in the pathogenesis of COPD, but its molecular mechanism of airflow limitation is still not elucidated. In recent years, protease / anti-protease imbalance and the pathogenesis of COPD have made great progress, this article is reviewed.